From May 10 to 16, 2025, the world’s brightest young scientists have gathered in Columbus, Ohio, for the 75th annual Regeneron International Science and Engineering Fair (ISEF). Widely regarded as the “World Cup of youth science competitions,” ISEF remains the largest and most prestigious STEM competition for high school students globally. This year’s event is significant as it marks ISEF’s 75th anniversary—a historic milestone in inspiring innovation and scientific excellence.

ISEF: Inspiring Global Youth Through Science

Since its inception, ISEF has been dedicated to nurturing young minds with a passion for science, technology, and innovation. The competition spans 22 subject categories: Physics, Chemistry, Computer Science, Engineering, Social Sciences, and Biology. Beyond showcasing cutting-edge research, ISEF is a launchpad for young talents, many of whom go on to attend top-tier universities and become future leaders in STEM fields.

Key Competition Details

1.Location and Dates

The 2025 ISEF Finals are being held at the Greater Columbus Convention Center in Columbus, Ohio, from May 10–16. Detailed venue information will be released closer to the event.

2.How to Qualify

Students can’t directly register for ISEF—they must first succeed in one of the affiliated regional or national fairs in their country or region.

• Mainland China: Sichuan Science & Engineering Fair, Youth Talent Program, and National Youth Science & Technology Innovation Contest

• Hong Kong: ISEF Hong Kong Preliminary, Hong Kong Youth Science and Technology Innovation Competition

• Singapore: Singapore Science and Engineering Fair (SSEF)

These fairs involve multiple stages, including project submission, peer review, and final evaluations, with top students advancing to the ISEF finals.

How to Prepare for the Finals

1.Project Review: SRC/IRB Compliance

Ensure that your research meets ISEF’s standards for ethical and scientific review. Even if your forms passed initial online checks, a final in-person review is essential. Double-check that all SRC (Scientific Review Committee) or IRB (Institutional Review Board) forms are complete, accurate, and compliant with ISEF’s ethics policies.

2.Materials Checklist

Prepare your poster board—a central element of your presentation. While the printed and digital versions don’t need to be identical, both must meet ISEF’s format and academic standards. If last-minute edits are needed, patching corrections is allowed—accuracy always takes priority.

Also, make sure to bring:

• ISEF-required forms and any necessary permission documents (e.g., photo release forms)

• Research logs that document your process

• A full-length research paper for detailed insights

• Your actual project (invention, app, prototype, etc.), with backup visuals or videos if physical display is limited

• Essential tools for maintenance or emergency fixes

3.Judging & Q&A Readiness

Memorizing your poster won’t be enough. Judges want to hear a logical and engaging narrative—how your idea evolved, what methods you used, and why your conclusions matter. Be prepared to discuss:

• Background and goals

• Methodology and challenges

• Real-world applications and limitations

• Future research directions

Confidence, clarity, and adaptability are key.

4.On-Site Presentation

Create an interactive and visually compelling display. Videos, demo models, and computer simulations can help bring abstract ideas to life. Ensure your area is clean, organized, and showcases your passion for your work.

5.Teamwork Makes the Dream Work

For team projects, make sure responsibilities are clearly assigned. Practice smooth transitions during presentations and support one another during judge interactions. Present a unified, professional image throughout.

What’s New in 2025

1.Global Talent

Nearly 2,000 students from 75 countries and regions are competing this year. These young scientists are the best of the best—winners from regional competitions now facing off on the world stage.

2.75th Anniversary Celebration

To honor this special year, ISEF is hosting a retrospective celebration, highlighting the competition’s evolution and its global impact on science education. Attendees can expect interactive exhibits, alumni guest speakers, and surprise moments commemorating ISEF’s legacy.

3.Enriching Experiences Beyond the Contest

The event week isn’t just about judging. ISEF 2025 includes:

4.Prizes & Recognition

This year’s awards total over $5 million in scholarships, grants, and cash prizes. The top honor, the Gordon E. Moore Award, offers a staggering $75,000—a testament to the value of groundbreaking youth research. Finalists also earn certificates, trophies, and global recognition that bolster future academic and career paths.

Final Thoughts

As technology rapidly evolves and the need for innovation grows, ISEF continues to play a vital role in shaping the future of science. With stronger international cooperation and broader educational outreach, the fair is more than a competition—it’s a movement to inspire the next generation of changemakers.

The 2025 ISEF Week has officially begun, and the excitement is palpable. Stay tuned as we follow this electrifying journey of discovery, talent, and passion for science!